PAX6 Antibody

PAX6 Antibody is an antibody targeting to PAX6.

The related gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster related gene prd. In addition to a conserved paired box domain, a hallmark feature of The related gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of related gene transcription. Activity of The protein is key in the development of neural tissues, particularly the eye. The related gene is regulated by multiple enhancers located up to hundreds of kilobases distant from The locus. Mutations in The related gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of related genes compared to the isoforms carrying the longer paired box domain.

Free

5080

Calculated MW: 47 kDa; Observed MW: 47 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

P26367

WB: 1/500-1/1000; IHC: 1/50-1/100; IF: 1/50-1/200

WB, IHC-P, ICC/IF

Liquid

Supplied in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human PAX6.