Phospho-MDM2 (Ser166) Antibody (YA1888)

Phospho-MDM2 (Ser166) Antibody (YA1888) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1888), targeting Phospho-MDM2 (Ser166), with a predicted molecular weight of 55 kDa (observed band size: 90 kDa). Phospho-MDM2 (Ser166) Antibody (YA1888) can be used for WB, IHC-P experiment in human, rat background.

The related gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. The related gene is itself transcriptionally-regulated by p53. Overexpression or amplification of The locus is detected in a variety of different cancers. There is a pseudorelated gene for The related gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

4193

Predicted band size: 55 kDa; Observed band size: 90 kDa

Affinity Purified

Non-conjugated

Phosphorylated

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Rat

Q00987

WB: 1/500-1/1000;IHC: 1/50-1/100

WB, IHC-P

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic phosphopeptide corresponding to residues surrounding Ser166 of human MDM2