Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631)

Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2631), targeting Phospho-PKC zeta/lambda (Thr410/Thr412), with a predicted molecular weight of 78 kDa (observed band size: 78 kDa). Phospho-PKC zeta/lambda (Thr410/Thr412) Antibody (YA2631) can be used for WB, IHC-P experiment in human, mouse background.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by The related gene is one of the PKC family members. The protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require The kinase. Knockout studies in mice also suggest that The kinase may be involved in neuropathic pain development. Defects in The protein have been associated with neuroderelated generative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for The related gene.

5582

Predicted band size: 78 kDa; Observed band size: 78 kDa

Affinity Purified

Non-conjugated

Phosphorylated

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse

P05129

WB: 1/500-1/1000;IHC: 1/50-1/100

WB, IHC-P

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic phosphopeptide corresponding to residues surrounding Thr410 of human PKC zeta