Phospho-Presenilin 2 (Ser330) Antibody (YA1878)

Phospho-Presenilin 2 (Ser330) Antibody (YA1878) is a biotin-conjugated non-conjugated IgG antibody, targeting Phospho-Presenilin 2 (Ser330), with a predicted molecular weight of 50 kDa (observed band size: 23 kDa). Phospho-Presenilin 2 (Ser330) Antibody (YA1878) can be used for WB experiment in human, mouse, rat background.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

5664

Predicted band size: 50 kDa; Observed band size: 23 kDa

Affinity Purified

Non-conjugated

Phosphorylated

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

P49810

WB: 1/500-1/1000

WB

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic phosphopeptide corresponding to residues surrounding Ser330 of human Presenilin 2