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  4. Phospho-Presenilin 2 (Ser330) Antibody (YA1878)

Phospho-Presenilin 2 (Ser330) Antibody (YA1878)

Cat. No.: HY-P82133
User Guide for Antibodies

Phospho-Presenilin 2 (Ser330) Antibody (YA1878) is a biotin-conjugated non-conjugated IgG antibody, targeting Phospho-Presenilin 2 (Ser330), with a predicted molecular weight of 50 kDa (observed band size: 23 kDa). Phospho-Presenilin 2 (Ser330) Antibody (YA1878) can be used for WB experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size Price Stock
10 μL $70 Ask For Quote & Lead Time
50 μL $185 Ask For Quote & Lead Time
100 μL $300 Ask For Quote & Lead Time

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Top Publications Citing Use of Products
  • Biological Activity

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Description

Phospho-Presenilin 2 (Ser330) Antibody (YA1878) is a biotin-conjugated non-conjugated IgG antibody, targeting Phospho-Presenilin 2 (Ser330), with a predicted molecular weight of 50 kDa (observed band size: 23 kDa). Phospho-Presenilin 2 (Ser330) Antibody (YA1878) can be used for WB experiment in human, mouse, rat background.

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Gene ID

5664

Synonyms
AD3LP; AD5; E5-1; STM-2
Molecular Weight

Predicted band size: 50 kDa; Observed band size: 23 kDa

Purity

Affinity Purified

Conjugation

Non-conjugated

Modification

Phosphorylated

Research Field

Neuroscience

Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Clonality

Recombinant, Monoclonal

Host

Rabbit

Reactivity

Human, Mouse, Rat

SwissProt ID

P49810

Dilution Ratio

WB: 1/500-1/1000

Application

WB

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Sensitivity

Endogenous

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser330 of human Presenilin 2

Documentation

Phospho-Presenilin 2 (Ser330) Antibody (YA1878) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Phospho-Presenilin 2 (Ser330) Antibody (YA1878)
Cat. No.:
HY-P82133
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