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  4. PMS2 Antibody (YA1772)

PMS2 Antibody (YA1772)

Cat. No.: HY-P82027
User Guide for Antibodies

PMS2 Antibody (YA1772) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA1772), targeting PMS2, with a predicted molecular weight of 96 kDa (observed band size: 150 kDa). PMS2 Antibody (YA1772) can be used for WB, IHC-P, ICC/IF experiment in human background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

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Description

PMS2 Antibody (YA1772) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA1772), targeting PMS2, with a predicted molecular weight of 96 kDa (observed band size: 150 kDa). PMS2 Antibody (YA1772) can be used for WB, IHC-P, ICC/IF experiment in human background.

Background

The protein encoded by The related gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. The protein forms heterodimers with the related gene product of the mutL homolog 1 (MLH1) related gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by The related gene that forms part of the active site of the nuclease. Mutations in The related gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.

Gene ID

5395

Synonyms
DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2
Molecular Weight

Predicted band size: 96 kDa; Observed band size: 150 kDa

Purity

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Research Field

Epigenetics and Nuclear Signaling

Product Categories

Primary Antibody; Mouse Monoclonal Antibody

Clonality

Monoclonal

Host

Mouse

Reactivity

Human

SwissProt ID

P54278

Dilution Ratio

WB: 1/500-1/1000 IHC: 1/50-1/100 ICC: 1/100-1/200

Application

WB, IHC-P, ICC/IF

Appearance

Liquid

Formulation

Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG2b

Sensitivity

Endogenous

Immunogen

Full length human recombinant protein of human PMS2 produced in 293T cell.

Documentation

PMS2 Antibody (YA1772) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PMS2 Antibody (YA1772)
Cat. No.:
HY-P82027
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