PMS2 Antibody (YA1772)

PMS2 Antibody (YA1772) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA1772), targeting PMS2, with a predicted molecular weight of 96 kDa (observed band size: 150 kDa). PMS2 Antibody (YA1772) can be used for WB, IHC-P, ICC/IF experiment in human background.

The protein encoded by The related gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. The protein forms heterodimers with the related gene product of the mutL homolog 1 (MLH1) related gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by The related gene that forms part of the active site of the nuclease. Mutations in The related gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.

5395

Predicted band size: 96 kDa; Observed band size: 150 kDa

Affinity Purified

Non-conjugated

Unmodified

Epigenetics and Nuclear Signaling

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

P54278

WB: 1/500-1/1000 IHC: 1/50-1/100 ICC: 1/100-1/200

WB, IHC-P, ICC/IF

Liquid

Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2b

Endogenous

Full length human recombinant protein of human PMS2 produced in 293T cell.