Presenilin 1 Antibody (YA1722)

Presenilin 1 Antibody (YA1722) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1722), targeting Presenilin 1, with a predicted molecular weight of 53 kDa (observed band size: 20 kDa). Presenilin 1 Antibody (YA1722) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for The related gene, the full-length nature of only some have been determined.

5663

Predicted band size: 53 kDa; Observed band size: 20 kDa

Affinity Purified

Non-conjugated

Unmodified

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

P49768

WB: 1/500-1/1000;IF: 1/50-1/200;IP: 1/20

WB, ICC/IF, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human Presenilin 1