2. Anti-infection Apoptosis
  3. Bacterial Apoptosis Necroptosis
  4. Anticancer agent 118

Anticancer agent 118, a N‑acylated ciprofloxacin derivative, has anti-bacterial and anticancer activities. Anticancer agent 118 shows high activity against Gram-positive strains and antiproliferative activities against prostate PC3 cells. Anticancer agent 118 can be used for antitumor research.

For research use only. We do not sell to patients.

Anticancer agent 118 Chemical Structure

Anticancer agent 118 Chemical Structure

CAS No. : 864443-43-6

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Anticancer agent 118 Related Antibodies

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Description

Anticancer agent 118, a N‑acylated ciprofloxacin derivative, has anti-bacterial and anticancer activities. Anticancer agent 118 shows high activity against Gram-positive strains and antiproliferative activities against prostate PC3 cells. Anticancer agent 118 can be used for antitumor research[1].

In Vitro

Anticancer agent 118 (Compound 3) (0-100 μΜ; 72 hours) shows high antiproliferative activities against prostate PC3 cells and induces apoptosis/necrosis in PC3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 118 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Prostate PC3 and HaCaT cells
Concentration: 0-100 μΜ
Incubation Time: 72 hours
Result: Showed high antiproliferative activities against prostate PC3 cells with an IC50 of 2.02 μM.
Reduced the growth and proliferation rates in prostate PC3cells, without acytotoxic action against normal HaCaT cell lines.
Induced apoptosis/necrosis in PC3 cells by increasing the intracellular ROS amount and diminished the IL-6 level in tumor cells.
Molecular Weight

407.82

Formula

C19H19ClFN3O4
CAS No.
SMILES

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCN(C(CCl)=O)CC4)=C3)C1=O)O
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Room temperature in continental US; may vary elsewhere.
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References
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Anticancer agent 118 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 118864443-43-6Anticancer agent118Anticancer agent-118BacterialApoptosisNecroptosisAntibacterialanticancerPC3HaCaT cellsGram-positive strainsInhibitorinhibitorinhibit

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