2. Apoptosis
  3. IAP
  4. Anticancer agent 128

Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively.

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Anticancer agent 128 Chemical Structure

Anticancer agent 128 Chemical Structure

CAS No. : 2941243-62-3

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Anticancer agent 128 Related Antibodies

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cIAP cIAP-1 cIAP-2 XIAP

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Description

Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively[1].

IC50 & Target

IC50: 27.2 nM (XIAP-BIR3), 16.6 nM (cIAP1-BIR3), and 8.4 nM (cIAP2-BIR3)[1]
Molecular Weight

470.60

Formula

C26H38N4O4
CAS No.
SMILES

O=C(N1[C@H](C(N[C@H]2C(C=CC=C3O)=C3CC2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 128 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1282941243-62-3Anticancer agent128Anticancer agent-128IAPXIAPcIAP1cIAP2BIR3 domainsInhibitorinhibitorinhibit

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