2. Apoptosis Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Autophagy Reactive Oxygen Species
  4. Anticancer agent 194

Anticancer agent 194 (compound 10p) is a ferroptosis and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS.

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Anticancer agent 194 Chemical Structure

Anticancer agent 194 Chemical Structure

CAS No. : 2767204-90-8

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Anticancer agent 194 Related Antibodies

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Description

Anticancer agent 194 (compound 10p) is a ferroptosis and autophagy inducer. Anticancer agent 194 arrests colon cancer cell cycle at G2/M phase, but can't induce cell apoptosis. Anticancer agent 194 independently triggeres cell ferroptosis and autophagy through the massive accumulation of ROS[1].

In Vitro

Anticancer agent 194 (compound 10p; 1-10 μM; 48 h) presents antiproliferative activity against HT-29 cancer cells with an IC50 of 1.97 μM[1].
Anticancer agent 194 (compound 10p; 1-4 μM; 48 h) arrests cell cycle at G2/M phase in a concentration-dependent manner[1].
Anticancer agent 194 (compound 10p; 0.5-4 μM; 48 h) decreases the expression of GPX4 in a concentration-dependent manner[1].
Anticancer agent 194 (compound 10p; 1-4 μM; 48 h) induces HT-29 cells autophagy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 194 Related Antibodies

Cell Viability Assay[1]

Cell Line: HT-29 cells
Concentration: 1 μM, 5 μM and 10 μM
Incubation Time: 48 h
Result: Induced cell death.

Cell Cycle Analysis[1]

Cell Line: HT-29 cells
Concentration: 1 μM, 2 μM and 4 μM
Incubation Time: 48 h
Result: Arrested cell cycle at G2/M phase.

Western Blot Analysis[1]

Cell Line: HT-29 cells
Concentration: 0.5 μM, 1 μM, 2 μM and 4 μM
Incubation Time: 48 h
Result: Decreased the expression of GPX4 in a concentration-dependent manner.

Cell Autophagy Assay[1]

Cell Line: HT-29 cells
Concentration: 1 μM, 2 μM and 4 μM
Incubation Time: 48 h
Result: Induced autophagy of HT-29 cells.
Molecular Weight

269.73

Formula

C12H16ClN3O2
CAS No.
SMILES

O=C(NCCCl)N1C2=CC=C(OC)C=C2NCC1
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
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Anticancer agent 194 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1942767204-90-8Anticancer agent194Anticancer agent-194FerroptosisAutophagyReactive Oxygen Speciesferroptosis inducerautophagycell cycle at G2/M phaseROSInhibitorinhibitorinhibit

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