2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Anticancer agent 225

Anticancer agent 225 (Comp 51) is a triterpenoic acids analogue which exhibits suppressive effect on elimination of different type of cancer stem cells (CSCs) and increase the ROS level of CSCs. Anticancer agent 225 can be used for cancer research.

For research use only. We do not sell to patients.

Anticancer agent 225 Chemical Structure

Anticancer agent 225 Chemical Structure

CAS No. : 2251753-61-2

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Based on 1 publication(s) in Google Scholar

Anticancer agent 225 Related Antibodies

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Description

Anticancer agent 225 (Comp 51) is a triterpenoic acids analogue which exhibits suppressive effect on elimination of different type of cancer stem cells (CSCs) and increase the ROS level of CSCs. Anticancer agent 225 can be used for cancer research[1].

Cellular Effect
Cell Line Type Value Description References
4T1 IC50
1.536 μM
Compound: 51
Cytotoxicity activity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
A-375 IC50
0.8274 μM
Compound: 51
Cytotoxicity activity against human A375 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human A375 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
A-375 IC50
2.4 μM
Compound: 51
Cytotoxicity against human A375 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
Cytotoxicity against human A375 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
[PMID: 30433783]
A549 IC50
9.891 μM
Compound: 51
Cytotoxicity activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
B16-F10 IC50
1.084 μM
Compound: 51
Cytotoxicity activity against mouse B16F10 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse B16F10 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
B16-F10 IC50
1.59 μM
Compound: 51
Cytotoxicity against mouse B16F10 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
Cytotoxicity against mouse B16F10 spheroid cells assessed as reduction in spheroid cell viability after 48 hrs by MTT assay
[PMID: 30433783]
Lewis lung carcinoma cell line IC50
1.022 μM
Compound: 51
Cytotoxicity activity against mouse LLC cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse LLC cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
MDA-MB-231 IC50
5.582 μM
Compound: 51
Cytotoxicity activity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
PANC-1 IC50
1.24 μM
Compound: 51
Cytotoxicity activity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
In Vitro

Anticancer agent 225 exerts IC50s of 2.4 and 1.59 μM against A375 and B16F10 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 225 Related Antibodies
In Vivo

Anticancer agent 225 (5 mg/kg, i.p., daily for 15 d) inhibits the tumor growth in C57BL/6 and Balb/C nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

673.99

Formula

C41H59N3O3S
CAS No.
SMILES

COC(C=C1)=CC=C1NC(NCCNC([C@]23[C@](CC(C)(CC3)C)([H])C4=CC[C@@]([C@@]5([C@@](C(C)(C(C(C5)=C)=O)C)([H])CC6)C)([H])[C@]6(C)[C@@]4(CC2)C)=O)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 225 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 2252251753-61-2Anticancer agent225Anticancer agent-225Reactive Oxygen SpeciestriterpenoicROSCSCscancerInhibitorinhibitorinhibit

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