2. Apoptosis Autophagy
  3. Apoptosis Mitophagy
  4. Anticancer agent 227

Anticancer agent 227 (compound YNU-1c) is a potent anticancer agent. Anticancer agent 227 shows antiproliferative activity. Anticancer agent 227 induces apoptosis and mitophagy.

For research use only. We do not sell to patients.

Anticancer agent 227 Chemical Structure

Anticancer agent 227 Chemical Structure

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Anticancer agent 227 Related Antibodies

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Description

Anticancer agent 227 (compound YNU-1c) is a potent anticancer agent. Anticancer agent 227 shows antiproliferative activity. Anticancer agent 227 induces apoptosis and mitophagy[1].

In Vitro

Anticancer agent 227 (compound YNU-1c) (0-50 µM; 48 h) shows antiproliferative activity with IC50s of 0.19, 0.13, >50 µM for HepG2, HCC1806, HL-7702 cells, respectively[1].
Anticancer agent 227 (0.13 µM; 48 h) induces apoptosis by increasing the expression of cytochrome c and cleaved caspase-3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 227 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HepG2, HCC1806, HL-7702, SF1, SF2 cells
Concentration: 0-50 μM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 0.19, 0.13, >50, >384.6, >263.2 μM for HepG2, HCC1806, HL-7702, SF1, SF2 cells, respectively.

Western Blot Analysis[1]

Cell Line: HCC1806 cells
Concentration: 0.13 µM
Incubation Time: 48 h
Result: Upregulated the expression of cytochrome c and cleaved caspase-3.
In Vivo

Anticancer agent 227 (5 mg/kg; i.p.; every 2 days for 21 days) shows antitumor activity in HCC1806 tumor-bearing nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice (HCC1806 cells)[1]
Dosage: 5 mg/kg
Administration: I.p.; every 2 days for 21 days
Result: Effectively inhibited HCC1806 tumor growth, reduced tumor weight with a tumor growth inhibition rate of 58.9 %.
Molecular Weight

854.78

Formula

C38H27Cl5N2O2PRh
SMILES

Cl[Rh]1([P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)OC5=C6C(C=CC(C)=[N]61)=C(Cl)C=C5Cl.[2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 227 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 227Anticancer agent227Anticancer agent-227ApoptosisMitophagyMitochondrial Autophagyantiproliferativeanticancer agentapoptosismitophagyHCC1806 cellsInhibitorinhibitorinhibit

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