2. Apoptosis Autophagy
  3. Apoptosis Autophagy Ferroptosis
  4. Anticancer agent 251

Anticancer agent 251 (compound 7j) can induce cell death of bladder cancer cell T24 by inducing apoptosis, autophagy or ferroptosis.

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Anticancer agent 251 Chemical Structure

Anticancer agent 251 Chemical Structure

CAS No. : 1648546-79-5

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Anticancer agent 251 Related Antibodies

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Description

Anticancer agent 251 (compound 7j) can induce cell death of bladder cancer cell T24 by inducing apoptosis, autophagy or ferroptosis[1].

Cellular Effect
Cell Line Type Value Description References
Bel-7402 IC50
5.77 μM
Compound: 7j
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32827851]
MGC-803 IC50
5.21 μM
Compound: 7j
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32827851]
T-24 IC50
3.97 μM
Compound: 7j
Antiproliferative activity against human T-24 cells assessed as reduction in cell viability measured upto 72 hrs by MTT assay
Antiproliferative activity against human T-24 cells assessed as reduction in cell viability measured upto 72 hrs by MTT assay
[PMID: 32827851]
Molecular Weight

438.31

Formula

C22H17Cl2N5O
CAS No.
SMILES

ClC1=CC(NC(NC2=CC=CC(CNC3=C4C(C=CC=C4)=NC=N3)=C2)=O)=CC=C1Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 251 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 2511648546-79-5Anticancer agent251Anticancer agent-251ApoptosisAutophagyFerroptosisQuinazolinyl-arylureaStructure-activity relationshipInhibitorinhibitorinhibit

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