2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 32

Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer.

For research use only. We do not sell to patients.

Anticancer agent 32 Chemical Structure

Anticancer agent 32 Chemical Structure

CAS No. : 2222930-76-7

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Anticancer agent 32 Related Antibodies

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Description

Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer[1].

IC50 & Target

IC50: 17.2 μM (MGC-803), 12.3 μM (HeLa), 40.6 μM (NCI-H460), 46.8 μM (HepG2), 95.4 μM (SMMC-7721), 8.9 μM (T-24), 86.8 μM (HL-7702)[1]
In Vitro

Anticancer agent 32 (2.5-40 μM; 48 h) shows cytotoxic activities to cancer cell lines[1].
Anticancer agent 32 (0-16 μM; 24 h) affects cell cycle, induces cell apoptosis, increases intracellular levels of Ca2+ and ROS[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 32 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cell lines
Concentration: 2.5, 5, 10, 20 and 40 μM
Incubation Time: 48 hours
Result: Inhibited cell growth with IC50 values of 17.2, 12.3, 40.6, 46.8, 95.4, 8.9 and 86.8 μM for MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: MGC-803 and T-24 cell lines
Concentration: 0, 8 and 12 μM
Incubation Time: 24 hours
Result: Significantly induced cell cycle arrest at the G2/M phase in T-24 cells.

Western Blot Analysis[1]

Cell Line: MGC-803 and T-24 cell lines
Concentration: 4, 8 and 12 μM
Incubation Time: 24 hours
Result: Decreased expression level of cyclin B1.

Apoptosis Analysis[1]

Cell Line: MGC-803 and T-24 cell lines
Concentration: 0, 4, 8 and 16 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis of T-24 cells from 8.21 to 32.91% after treatment by increasing levels of caspase-3 and caspase-9 in T-24 cells.
Molecular Weight

433.45

Formula

C24H21F2N5O
CAS No.
SMILES

CC1=CC(C)=CC(NC(NC2=CC=CC(CNC3=NC4=CC(F)=C(C=C4N=C3)F)=C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 322222930-76-7Anticancer agent32Anticancer agent-32ApoptosisquinoxalinesorafenibchemotherapyanticancerMGC-803HeLaNCI-H460apoptosiscell cycleROSInhibitorinhibitorinhibit

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