2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis ROS Kinase
  4. Anticancer agent 59

Anticancer agent 59 (compound 11) has inhibitory activity against kinds of cancer cell lines, especially in A549 with IC50 of 0.2 μM. Anticancer agent 59 induces apoptosis and an increase of Ca2+ and ROS in cancer cells. Anticancer agent 59 significantly decreases mitochondrial membrane potential. Anticancer agent 59 can suppress tumor growth in A549 mouse xenograft model.

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Anticancer agent 59 Chemical Structure

Anticancer agent 59 Chemical Structure

CAS No. : 2366170-11-6

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Anticancer agent 59 Related Antibodies

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Description

Anticancer agent 59 (compound 11) has inhibitory activity against kinds of cancer cell lines, especially in A549 with IC50 of 0.2 μM. Anticancer agent 59 induces apoptosis and an increase of Ca2+ and ROS in cancer cells. Anticancer agent 59 significantly decreases mitochondrial membrane potential. Anticancer agent 59 can suppress tumor growth in A549 mouse xenograft model[1].

IC50 & Target

IC50: 0.2 μM in A549[1]
Molecular Weight

673.92

Formula

C42H59NO6
CAS No.
SMILES

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@@](C)(C4)C(N[C@H](C(O)=O)CC5=CC=CC=C5)=O)C)=CC([C@]1([H])[C@@]6([C@@](C(C)([C@H](CC6)OC(CC)=O)C)([H])CC2)C)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 59 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 592366170-11-6Anticancer agent59Anticancer agent-59ApoptosisROS KinaseAnticancerAntitumorA549T24Xenograft modelMitochondrial membrane potentialInhibitorinhibitorinhibit

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