2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Anticancer agent 60

Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC50 = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model.

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Anticancer agent 60 Chemical Structure

Anticancer agent 60 Chemical Structure

CAS No. : 2162169-14-2

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Description

Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC50 = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model[1].

IC50 & Target

IC50: 4.13 ± 0.54 μM in HepG2, 6.06 ± 0.46 μM in Bel-7402, 15.04 ± 0.74 μM in MCF-7[1]
Cellular Effect
Cell Line Type Value Description References
Bel-7402 IC50
6.06 μM
Compound: 3h
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
[PMID: 32113125]
HepG2 IC50
4.13 μM
Compound: 3h
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
[PMID: 32113125]
MCF7 IC50
15.04 μM
Compound: 3h
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
[PMID: 32113125]
Molecular Weight

523.65

Formula

C27H33N5O4S
CAS No.
SMILES

COC1=NC(OC)=C(C=C1)N(S(=O)(C2=CC3=C(N(C4=C3C=CC=C4)C)C=C2)=O)CCN5CCN(CC5)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 60 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 602162169-14-2Anticancer agent60Anticancer agent-60Microtubule/TubulinAnticancerAntitumorAntiproliferativeHepG2Bel-7402MCF-7Xenograft mouse modelInhibitorinhibitorinhibit

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