Antifreeze Polypeptide 6 (winter flounder)

Name: Antifreeze Polypeptide 6 (winter flounder)
Brand: MedChemExpress
SKU: HY-P3832
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3832 Purity: 99.84%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Antifreeze Polypeptide 6 (winter flounder) Chemical Structure

CAS No. : 122604-16-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

In Vitro

Antifreeze Polypeptide 6 (winter flounder) inhibits the growth of ice crystals by hydrogen bonding of Thr, Asn, and Asp side chains in a specific pattern to the hexagonal bipyramidal planes of ice. This mode of binding is unidirectional, maximizing opportunities for packing of AFPs on the ice surface, and that ice crystal growth inhibition occurs by a two-step mechanism involving hydrogen bonding and hydrophobic interpeptide interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3242.47

Formula

C₁₃₃H₂₂₅N₄₃O₅₁

CAS No.

122604-16-4

Appearance

Solid

Color

White to off-white

Sequence Shortening

DTASDAAAAAALTAANAKAAAELTAANAAAAAAATAR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 45.45 mg/mL (14.02 mM; adjust pH to 1 with 1 M HCL)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3084 mL	1.5420 mL	3.0841 mL
5 mM	0.0617 mL	0.3084 mL	0.6168 mL
10 mM	0.0308 mL	0.1542 mL	0.3084 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (243 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Wen D, et al. A model for binding of an antifreeze polypeptide to ice. Biophys J. 1992 Dec;63(6):1659-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.3084 mL	1.5420 mL	3.0841 mL	7.7102 mL
	5 mM	0.0617 mL	0.3084 mL	0.6168 mL	1.5420 mL
	10 mM	0.0308 mL	0.1542 mL	0.3084 mL	0.7710 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.