Antifungal agent 106 

Antifungal agent 106 (Compound Z31) is a benzoic acid derivative and a potential fungicide against Monilinia fructicola. Antifungal agent 106 exhibits antifungal activity with an EC₅₀ value of 11.8 mg/L. It affects hyphal growth by disrupting cell membrane integrity, leading to increased membrane permeability and release of intracellular electrolytes. Antifungal agent 106 can be used in research related to brown rot of stone fruits^[1].

Antifungal agent 106 (3.125-50 mg/L) exhibits inhibitory activity against M. fructicola, inhibiting spore germination and mycelial formation. It induces the production of excess endogenous reactive oxygen species (ROS) in M. fructicola, leading to oxidative damage, enzyme inactivation, and cell membrane disruption^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 106 treatment (100 mg/L and 200 mg/L, spray, 24-hour application duration) on plant tissues (pears) exhibited significantly lower incidence of brown rot and smaller lesion diameters, indicating that Antifungal agent 106 has inhibitory activity against stone fruit brown rot^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

434.30

C₂₀H₂₁BrFN₃O₂

BrC1=CC=C(C(C(NC2=CC=CC(F)=C2)=O)N3CCN(C(C)=O)CC3)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zheng Y, et al. Novel mandelic acid derivatives containing piperazinyls as potential candidate fungicides against Monilinia fructicola: Design, synthesis and mechanism study. Bioorg Chem. 2024 Jul 15;151:107647.  [Content Brief]