Antifungal agent 38 

Antifungal agent 38 is a geterocyclic disulfide, an antifungal and antibacterial agent. Antifungal agent 38 induces the shrinkage of hyphae, disrupts the integrity of the plasma membrane, and causes the damage and leakage of cell contents^[1].

Antifungal agent 38 (50 μg/mL) shows anti-fungal activity against 10 pathogenic fungi with inhibition rates of 56.57% (R. solani), 100% (S. sclerotiorum), 55.09% (B. cinerea), 71.23% (F. graminearum), 37.32% (M. oryzae), 50.87% (P. capsici), 100% (A. flavus), 59.75% (P. expansum), 100% (M. fructicola), 65.78% (R. stolonifer), respectively^[1].
Antifungal agent 38 (5 μg/mL) damages plasma membrane integrity of M. fructicola^[1].
Antifungal agent 38 (100 μg/mL) displays excellent anti-bacterial activity against X. oryzae accc 11602, X. axonpodis^[1].
Antifungal agent 38 inhibits fungus growth with EC₅₀s of 17.09 μg/mL (R. solani), 6.34 μg/mL (S. sclerotiorum), 25.24 μg/mL (F. graminearum), >10 μg/mL (A. flavus), 10.42 μg/mL (M. fructicola), 45.71 μg/mL (B. cinerea), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 38 (compound S8) (200 μg/mL) displays equivalent curative and higher protective effects as the positive drug Thiophanate-Methyl (HY-B0842) in vivo^[1].
Antifungal agent 38 (50, 100, 200 μg/mL, 30 mL; sprinkling) applies on pears and inhibits M. fructicola growth in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

200.32

C₈H₁₂N₂S₂

2833772-94-2

CC(CSSC1=NC=CC=N1)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang JR, et al. Allicin-Inspired Heterocyclic Disulfides as Novel Antimicrobial Agents. J Agric Food Chem. 2022 Sep 6.   [Content Brief]