2. Anti-infection
  3. Fungal
  4. Antifungal agent 53

Antifungal agent 53 (A03) is a potent inhibitor of Candida albicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety.

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Antifungal agent 53 Chemical Structure

Antifungal agent 53 Chemical Structure

CAS No. : 2422019-76-7

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Antifungal agent 53 Related Antibodies

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Description

Antifungal agent 53 (A03) is a potent inhibitor of Candida albicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety[1].

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
1.02 μM
Compound: A03
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 33713977]
MCF-10A IC50
30.16 μM
Compound: A03
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 33713977]
MDA-MB-231 IC50
9.06 μM
Compound: A03
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 33713977]
PC-3 IC50
13.1 μM
Compound: A03
Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 33713977]
In Vitro

Antifungal agent 53 (4 μg/mL; 24 h) displayed less hemolytic effect than Miconazole (HY-B0454), against rabbit red blood cells[1].
Antifungal agent 53 (50 μg/mL, 80 μg/mL; 1.5-24 h) inhibits the formation of C. albicans biofilm in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 53 Related Antibodies
Molecular Weight

444.64

Formula

C18H15Cl3N2Se
CAS No.
SMILES

ClC1=CC=C(C([Se]CC2=CC=CC=C2Cl)CN3C=CN=C3)C(Cl)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antifungal agent 53 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent 532422019-76-7Antifungal agent53Antifungal agent-53FungalInhibitorinhibitorinhibit

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