Antifungal agent 59 

Antifungal agent 59 is an antifungal agent, with MIC values of 0.01-1 μg/mL. Antifungal agent 59 prevents the formation of fungi biofilms, but also has safety^[1].

Antifungal agent 59 (compound A23) shows in vitro antifungal activity with MIC values of 0.02 μg/mL (Candida albicans), 0.01 μg/mL (Candida albicans), 0.25 μg/mL (Candida zeylanoides), 0.25 μg/mL (Cryptococcus neoformans), 0.06 μg/mL (Candida kruseii), 1 μg/mL (Candida glabrata), 0.02 μg/mL (Candida parapsilosis), and 1 μg/mL (Aspergillus fumigatus), respectively^[1].
Antifungal agent 59 (0.02 μg/mL ;48 h) potently kills Candida albicans^[1].
Antifungal agent 59 (1-16 μg/mL) shows hemolytic activity against rabbit red blood cells, with 93.47% hemolysis at concentrations of 8 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

456.19

C₁₈H₁₅BrF₂N₂Se

2422019-96-1

FC1=CC=C(C([Se]CC2=CC=CC=C2Br)CN3C=CN=C3)C(F)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xu H, et al. Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents. Eur J Med Chem. 2020 Jul 15;198:112360.  [Content Brief]