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  3. Fungal
  4. Antifungal agent 72

Antifungal agent 72 (Compound B8) is a potent antifungal agent. Antifungal agent 72 suppresses the function of efflux pump and down-regulates the resistance-associated genes through blocking the Pdr1-KIX interaction (Ki: 11.7 μM). Antifungal agent 72 is active against Fluconazole (HY-B0101)-resistant with a MIC value of 63 ng/mL, and shows synergistic inhibitory activity with Fluconazole. Antifungal agent 72 can be used for C. glabrata infection research.

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Antifungal agent 72 Chemical Structure

Antifungal agent 72 Chemical Structure

CAS No. : 3032485-62-1

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Antifungal agent 72 Related Antibodies

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Description

Antifungal agent 72 (Compound B8) is a potent antifungal agent. Antifungal agent 72 suppresses the function of efflux pump and down-regulates the resistance-associated genes through blocking the Pdr1-KIX interaction (Ki: 11.7 μM). Antifungal agent 72 is active against Fluconazole (HY-B0101)-resistant with a MIC value of 63 ng/mL, and shows synergistic inhibitory activity with Fluconazole. Antifungal agent 72 can be used for C. glabrata infection research[1].

IC50 & Target

Pdr1-KIX interaction[1]
Molecular Weight

274.34

Formula

C13H14N4OS
CAS No.
SMILES

NC1=CC(N(N1)C(NC2=CC3=C(CCC3)C=C2)=S)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antifungal agent 72 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent 723032485-62-1Antifungal agent72Antifungal agent-72FungalinfectionFluconazolesynergisticantifungalC. glabrataPdr1-KIXInhibitorinhibitorinhibit

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