Antifungal agent 84 

Antibacterial agent 84 is an antifungal compound. Antibacterial agent 84 inhibits candidiasis in a CNB1-dependent way. Antibacterial agent 84 inhibits the C. albicans biofilm's viability^[1].

Antibacterial agent 84 (compound 6d) (1-16 μg/mL) inhibits human pathogen C. albicans SC5314 growth^[1].
Antibacterial agent 84 (16 μg/mL, 18 h) induces endogenous reactive oxygen species (ROS) production in C. albicans in a CNB1-dependent way^[1].
Antibacterial agent 84 (16 μg/mL, 18 h) is cytotoxic against lysosomal membrane permeabilization in C. albicans^[1].
Antibacterial agent 84 (16 μg/mL, 18 h) induces C. albicans phagocytosis by macrophages^[1].
Antibacterial agent 84 (0.06-32 μg/mL) inhibits ergosterol synthesis in in cultures of C. albicans and C. tropicalis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 84 (16 μg/mL, injected into the right pro-leg) aids in the clearance of fungi 1 h post-infection in G. mellonella larvae infected by C. albicans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

553.81

C₂₅H₁₉BrClFN₆O

2901064-07-9

ClC(C=CC=C1)=C1C2=NN(N=N2)CCCN3C(CN=C(C4=C3C=CC(F)=C4)C5=C(C=CC=C5)Br)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Staniszewska M, et al. Tetrazole derivatives bearing benzodiazepine moiety-synthesis and action mode against virulence of Candida albicans. Eur J Med Chem. 2022 Feb 15;230:114060.  [Content Brief]