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  4. Antifungal agent 96

Antifungal agent 96 (Compound WZ-2) is an antifungal agent with good blood-brain barrier permeability and brain penetration. Antifungal agent 96 inhibits the growth of C. neoformans H99 and C. albicans 0304103 with MIC values of 0.016 and 32 μg/mL, respectively.

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Antifungal agent 96 Chemical Structure

Antifungal agent 96 Chemical Structure

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Antifungal agent 96 Related Antibodies

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Description

Antifungal agent 96 (Compound WZ-2) is an antifungal agent with good blood-brain barrier permeability and brain penetration. Antifungal agent 96 inhibits the growth of C. neoformans H99 and C. albicans 0304103 with MIC values of 0.016 and 32 μg/mL, respectively[1].

In Vitro

Antifungal agent 96 (0.063, 2μg/mL; 24 h) significantly inhibits the capsule growth of C. neoformans H99 [1].
Antifungal agent 96 (0.063μg/mL; 24h) inhibits the biofilm formation of C. neoformans H99 with an inhibition rate exceeding 90%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 96 Related Antibodies
In Vivo

Antifungal agent 96 (5 mg/kg; i.v.; daily; 3 days) shows potent antifungal efficacy against C. neoformans and C. albicans in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: cryptococcal meningitis (CM) mice[1]
Dosage: 5 mg/kg
Administration: IV; daily for 3 days
Result: Significantly reduced the kidney C. albicans 0304103 burden of mice and the brain C. neoformans H99 burden of CM mice.
Molecular Weight

248.26

Formula

C11H8N2O3S
SMILES

O=C(C1=C(/C2=N/OC)C=CS1)C3=C2ON=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antifungal agent 96 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent 96Antifungal agent96Antifungal agent-96FungalBiofilms,Rodent models,Toxicological synergyC. neoformansC. albicansInhibitorinhibitorinhibit

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