Antileishmanial agent-17

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Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC₅₀ <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC₅₀ value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

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Antileishmanial agent-17 Chemical Structure

CAS No. : 2934738-40-4

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Description	Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC₅₀ <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC₅₀ value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
In Vitro	Antileishmanial agent-17 (compound 14b) inhibits folate pathway with inhibitory rates of 82% and 91% against Folic acid, and 88% and 91% agaisnt Folinic acid, with 20 μM and 100 μM, respectivley^[1]. Antileishmanial agent-17 shows insignificant cytotoxicity against African green monkey kidney cells (VERO cells), with CC₅₀ of 244.3 μM^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Antileishmanial agent-17 Related Antibodies
Molecular Weight	511.61
Formula	C₂₇H₃₇N₅O₅
CAS No.	2934738-40-4
SMILES	O=C(NCCCCCCN1C=C(N=N1)CN2CCOCC2)C(C(O3)=O)=CC(C=C4)=C3C=C4OCCCC
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (263 KB) Handling Instructions (2659 KB)
References	[1]. Hassan NW, et al. Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies. Eur J Med Chem. 2023 May 5;253:115333. [Content Brief]