2. Anti-infection
  3. Parasite
  4. Antileishmanial agent-19

Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC50 of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals.

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Antileishmanial agent-19 Chemical Structure

Antileishmanial agent-19 Chemical Structure

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Antileishmanial agent-19 Related Antibodies

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Description

Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC50 of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals[1].

Molecular Weight

386.40

Formula

C22H18N4O3
SMILES

O=C(NC1=NC=CC=C1)COC2=CC=C(C(N3C)=NC4=C(C=CC=C4)C3=O)C=C2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Antileishmanial agent-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-19Antileishmanial agent19Antileishmanial agent 19ParasiteL. donovani promastigotesLeishmaniaAntileishmanialPI3K/Akt/CREB axisInhibitorinhibitorinhibit

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