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  4. Antileishmanial agent-5

Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent. Antileishmanial agent-4 is against L.infantum and T.cruzi with EC50 values of 0.68 μM and 0.83 μM, respectively.

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Antileishmanial agent-5 Chemical Structure

Antileishmanial agent-5 Chemical Structure

CAS No. : 2922333-29-5

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Antileishmanial agent-5 Related Antibodies

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Description

Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent. Antileishmanial agent-4 is against L.infantum and T.cruzi with EC50 values of 0.68 μM and 0.83 μM, respectively[1].

IC50 & Target

Leishmania

 

Cellular Effect
Cell Line Type Value Description References
MRC5 CC50
> 64 μM
Compound: 32
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 3 days by resazurin dye based fluorescence analysis
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 3 days by resazurin dye based fluorescence analysis
[PMID: 35533570]
Peritoneal macrophage CC50
> 64 μM
Compound: 32
Cytotoxicity against Swiss mouse peritoneal macrophages assessed as reduction in cell viability measured after 5 days by microscopic analysis
Cytotoxicity against Swiss mouse peritoneal macrophages assessed as reduction in cell viability measured after 5 days by microscopic analysis
[PMID: 35533570]
Molecular Weight

376.79

Formula

C17H17ClN4O4
CAS No.
SMILES

CC1=NC=NC2=C1C(C3=NC=CC(Cl)=C3)=CN2[C@@H]4O[C@@H]([C@H]([C@H]4O)O)CO
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antileishmanial agent-5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-52922333-29-5Antileishmanial agent5Antileishmanial agent 5ParasiteLeishmaniasisribonucleoside analogueantileishmanial agentT.cruziInhibitorinhibitorinhibit

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