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  3. Parasite
  4. Antimalarial agent 16

Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM).

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Antimalarial agent 16 Chemical Structure

Antimalarial agent 16 Chemical Structure

CAS No. : 2773408-33-4

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Antimalarial agent 16 Related Antibodies

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Description

Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM)[1].

IC50 & Target

IC50: 2.0 nM (P. falciparum)[1]
In Vivo

Antimalarial agent 16 (i.p.; 40 or 200 mg/kg; once daily; 4 days) exhibits significant in vivo antimalarial effects[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Plasmodium berghei (P. berghei) ANKA infected ICR mouse[1]
Dosage: 40 or 200 mg/kg
Administration: Intraperitoneal injection; 40 or 200 mg/kg; once daily; 4 days
Result: Inhibited malaria parasite growth effectively and retained parasitemia levels until day 8 post-infection at a dose of 40 mg/kg, attenuated parasitemia levels until day 8.
Maintained survival rates until day 11 post-infection, but the rates decreased rapidly after day 11 at a dose of 40 mg/kg, observed a significant enhancement in survival a dose of 200 mg/kg.
Molecular Weight

516.58

Formula

C30H32N2O6
CAS No.
SMILES

CCCCC1=CC(OC2=C1C(O[C@H](C)C(N3CC4=C(C5=C(N4)C=CC=C5)C[C@H]3C(OC)=O)=O)=CC(C)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antimalarial agent 16 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 162773408-33-4Antimalarial agent16Antimalarial agent-16Parasiteantimalarial activityP. falciparumInhibitorinhibitorinhibit

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