Antimalarial agent 25 

Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo^[1].

Antimalarial agent 25 (compound 8) inhibits P. falciparum with IC₅₀ of 4.2 μM, while shows CC₅₀ on mammalian cells with CC50s of 289.2 μM (HepG2), and 400.6 μM (Vero), respectively^[1].
Antimalarial agent 25 (compound 8) (15.62-1000 μM; 2 h) shows hemolytic activity below 40% at concentrations from 15.6 to 250 μM in uninfected human erythrocytes^[1].
Antimalarial agent 25 (compound 8) (30-0.411 μg/mL; 48 h) causes morphological changes such as complete cytoplasmic degradation and loss of membrane integrity in the W2 strain of P. falciparum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 25 (compound 8) (30 mg/kg; po; once daily for 4 consecutive days) shows antimalarial activity in female albino swiss mice^[1]. Antimalarial agent 25 (300 mg/kg; po; single dose) shows no significant pathological changes and histopathological damage in female mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

374.39

C₂₁H₁₈N₄O₃

2944456-41-9

COC1=CC=C(C=C1)C2=CN(N=N2)CCNC3=CC(C4=CC=CC=C4C3=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Costa Souza RM, et al. Biological activity of 1,2,3-triazole-2-amino-1,4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control. Eur J Med Chem. 2023 Jul 5;255:115400.  [Content Brief]