2. Anti-infection
  3. Parasite
  4. Antimalarial agent 26

Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo.

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Antimalarial agent 26 Chemical Structure

Antimalarial agent 26 Chemical Structure

CAS No. : 2299199-56-5

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Antimalarial agent 26 Related Antibodies

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Description

Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo[1].

In Vitro

Antimalarial agent 26 (compound 11) inhibits P. falciparum with IC50 of 2.7 μM, while shows CC50 on mammalian cells with CC50s of 440.9 μM (HepG2), and 1336 μM (Vero), respectively[1].
Antimalarial agent 26 (1000 to 15.62 μM; 2 h) shows hemolytic activity below 40% at concentrations from 250 to 15.6 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 26 Related Antibodies
In Vivo

Antimalarial agent 26 (compound 11) (30 mg/kg; po; once daily for 4 consecutive days) shows antimalarial activity in female albino swiss mice[1].
Antimalarial agent 26 (300 mg/kg; po; single dose) shows pathological lesions of hepatocellular damage in female mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female albino swiss mice[1]
Dosage: 300 mg/kg
Administration: PO; single dose
Result: Presented necrosis of hepatocytes in moderate to severe degrees, acidophilic cytoplasm with macro vacuoles and micro steatosis, granular degeneration and congestion of the lobular center vein and hepatic portal vein.
In the kidney, Resulted an atrophic glomerulus was observed with congested capillaries, reduction of mesangial cells and podocytes with discrete thickening of the basal membrane.
Molecular Weight

366.41

Formula

C20H22N4O3
CAS No.
SMILES

O=C1C=C(C(C2=C1C=CC=C2)=O)NCCN3N=NC(C4(CCCCC4)O)=C3
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References
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Antimalarial agent 26 Related Classifications

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Keywords:

Antimalarial agent 262299199-56-5Antimalarial agent26Antimalarial agent-26ParasiteP. FalciparumP. burgheiparasitemia1,4-naphthoquinonesInhibitorinhibitorinhibit

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