2. Anti-infection
  3. Parasite
  4. Antimalarial agent 49

Antimalarial agent 49 is an orally active antimalarial compound. Antimalarial agent 49 inhibits growth of Pf3D7 and PfK1 strains (IC50: 0.84 μM and 0.4 μM respectively). Antimalarial agent 49 has antimalarial activity and inhibits the development of P. berghei liver stages. Antimalarial agent 49 can be used in the study of Plasmodium infection.

For research use only. We do not sell to patients.

Antimalarial agent 49 Chemical Structure

Antimalarial agent 49 Chemical Structure

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Antimalarial agent 49 Related Antibodies

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Description

Antimalarial agent 49 is an orally active antimalarial compound. Antimalarial agent 49 inhibits growth of Pf3D7 and PfK1 strains (IC50: 0.84 μM and 0.4 μM respectively). Antimalarial agent 49 has antimalarial activity and inhibits the development of P. berghei liver stages. Antimalarial agent 49 can be used in the study of Plasmodium infection[1].

In Vitro

Antimalarial agent 49 (compound 15k) (0.37-10 μM, 40 h) inhibits the development of P. berghei liver stage (IC50: 5.88 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimalarial agent 49 Related Antibodies
Parmacokinetics[1]
Species Dose Route Indicator value
Mice 100 mg/kg p.o. T1/2 3.74 hr
Mice 100 mg/kg p.o. Tmax 4.00 hr
Mice 100 mg/kg p.o. Cmax 15.17 ng/mL
Mice 100 mg/kg p.o. Vd 4.97 L/kg
Mice 100 mg/kg p.o. CL 0.92 L/h/kg
Mice 100 mg/kg p.o. AUC 0.11 ng·h/mL
Mice 100 mg/kg p.o. MRT 7.30 hr
In Vivo

Antimalarial agent 49 (compound 15k) (100 mg/kg, p.o., once every day for 4 d) inhibits inhibits the growth of parasites in the P. yoelii N67 infected mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss mice (6-8-week-old, 18 ± 2 g) were intra-peritoneally inoculated with 1x106 P.yoelii N67 infected red blood cells (iRBCs)[1]
Dosage: 100 mg/kg
Administration: Oral gavage (p.o.), once every day for 4 d
Result: Inhibited 42.55% of parasite growth on the 7th day and 35.93% of parasite growth on the 10th day.
Prolonged the median survival time (17 d) compared with the Chloroquine (HY-17589A) (10 mg/kg)-treated group (16 d).
Molecular Weight

530.48

Formula

C28H18F4N6O
SMILES

O=C(C1=CC2=C(C(C3=CC=C(F)C=C3)=N1)NC4=C2C=CC=C4)NCC5=CN(C6=CC=CC(C(F)(F)F)=C6)N=N5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antimalarial agent 49 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 49Antimalarial agent49Antimalarial agent-49ParasiteAntimalarialHepG2 cellsmouse P. yoelii N67 infection modelpasmodium infectionInhibitorinhibitorinhibit

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