Antimicrobial agent-10 

Antimicrobial agent-10 is a SARS-CoV-2 inhibitor with outstanding antibacterial activity^[1].

Bacteria, SARS-CoV-2^[1]

Antimicrobial agent-10 (compound 4) shows inhibitory activity on coronavirus (SARS-CoV-2, HCoV-229E) replication and spike-mediated pseudovirus entry in Vero E6 cells, Calu-3 cells, A549-AT cells, with EC₅₀ values of 13-22 μM^[1].
Antimicrobial agent-10 inhibits cathepsin L, 3CL^Pro enzyme activity and the ACE2-spike interaction, with EC₅₀ values of 66 μM, 7.6 μM, 9 μM respectively^[1].
Antimicrobial agent-10 (0-10 μg/mL approximately) shows activity against diverse species of Gram-positive bacteria including drug-resistant strains^[1].
Antimicrobial agent-10 (0-100 μM, 2 h) inhibits SARS-CoV-2 pseudovirus entry in Vero and A549-AT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1844.29

C₇₈H₆₅Cl₂F₁₃N₁₀O₂₄

OC1=C(OC2=C(C=C(C=C2)[C@@]([H])(O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(C)=O)[C@]([H])(NC([C@@H]4N5)=O)C(N[C@H](C6=CC(O)=CC(O)=C6C7=CC4=CC=C7O)C(O)=O)=O)Cl)C=C(C=C1OC8=C(C=C(C=C8)C[C@]([H])9NC([C@@H]%10N%11N=NC(COCCCC(F)(C(F)(C(F)(C(F)(F)C(F)(C(F)(F)F)F)F)F)F)=C%11)=O)Cl)[C@H](C5=O)NC([C@@H](NC9=O)C%12=CC(OC%13=CC%10=CC=C%13O)=CC(O)=C%12)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ilona Bereczki, et al. Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria. Sci Rep. 2022 Sep 26;12(1):16001.  [Content Brief]