Antiparasitic agent-16 

Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-16 has IC₅₀s of 1.0 μM and 0.6 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-16 has IC₅₀s of 150.2 μM and 16.75 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-16 induces parasite cell death through necrosis induction. Antiparasitic agent-16 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes^[1].

Antiparasitic agent-16 (compound 15) has a CC₅₀ of 47.4 μM in RAW 264.7^[1].
Antiparasitic agent-16 (1.0, 2.0 μM; 24 h) promotes morphological changes such as shortening, retraction and curvature of the parasite body in trypomastigotes forms of T. cruzi. Antiparasitic agent-16 dose-dependently induces significant alterations compatible with apoptosis in trypomastigotes^[1].
Antiparasitic agent-16 (10 μg/mL; 24 h, 48 h, 72 h, and 96 h) causes a significant reduction in IL-10 production in supernatants of stimulated murine splenocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

338.43

C₁₈H₁₈N₄OS

CC(C1S/C(N(C1=O)C2=CC=CC=C2)=N/N=C/C3=CC=CC=N3)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Juliana Maria da Conceição, et al. Structural design, synthesis, and anti-Trypanosomatidae profile of new Pyridyl-thiazolidinones. Eur J Med Chem. 2023 Apr 6;254:115310.  [Content Brief]