Antiparasitic agent-25

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Antiparasitic agent-25 (Compounds 11) is an orally active antiparasitic agent. Antiparasitic agent-25 inhibits both parasite invasion and replication ability and has irreversible action against Toxoplasma gondii, significantly reducing the replication rate of Toxoplasma gondii with an IC₅₀ value of 6.33 μM, and demonstrates low cytotoxicity with a CC₅₀ value of 285 μM.

For research use only. We do not sell to patients.

Antiparasitic agent-25 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 6.33 μM (Toxoplasma gondii)^[1]

In Vitro

Antiparasitic agent-25 (10 μM, 24-72 h) reveals irreversible action of against Toxoplasma gondii^[1].
Antiparasitic agent-25 (10 μM; 30 min) significantly cut down the number of invaded parasites, indicating it can inhibit the invasion of parasites into host cells^[1].
Antiparasitic agent-25 (10 μM, 24 h) constrains the replication of the majority of tachyzoites to 0-1 cycles, manifesting a prevalence of vacuoles sized for accommodating only one or two tachyzoites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	HFF cells
Concentration:	10 μM
Incubation Time:	24 h
Result:	Constrained the replication of the majority of tachyzoites to 0-1 cycles, manifesting a prevalence of vacuoles sized for accommodating only one or two tachyzoites.

Cell Invasion Assay^[1]

Cell Line:	HFF cells
Concentration:	10 μM
Incubation Time:	30 min
Result:	Significantly cut down the number of invaded parasites, indicating could inhibit the invasion of parasites into host cells.

In Vivo

Antiparasitic agent-25 (50 mg/kg; p.o.; twice daily for 5 days) reduces parasite numbers, statistically significantly extends the median survival time, but insufficient to completely suppress the growth of parasites in vivo, leading to continued infection and consequently high mortality rates among infected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Kunming mice (eight-nine weeks old) (Inoculated with 1 × 10³ tachyzoites of the RH strain via intraperitoneal (ip) injection.)^[1]
Dosage:	50 mg/kg (Dissolved in PBS including 25% PEG-400 and 5% DMSO)
Administration:	Oral gavage (p.o.); twice daily for 5 days
Result:	Reduced parasite numbers, statistically significantly extended the median survival time, but insufficient to completely suppress the growth of parasites in vivo, leading to continued infection and consequently high mortality rates among infected mice.

Molecular Weight

531.60

Formula

C₃₂H₂₉N₅O₃

SMILES

O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)CN3CCN(C(N4C5=CC=CC=C5)=NC6=C(C=CC=C6)C4=O)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Deng Y, et al. Design, Synthesis, and Structure-Activity Relationship of 2-(Piperazin-1-yl)quinazolin-4(3H)-one Derivatives as Active Agents against Toxoplasma gondii. J Agric Food Chem. 2025 Mar 12;73(10):6215-6230. [Content Brief]