2. Anti-infection
  3. Parasite
  4. Antiparasitic agent-9

Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the human parasite.

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Antiparasitic agent-9 Chemical Structure

Antiparasitic agent-9 Chemical Structure

CAS No. : 2516237-50-4

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Antiparasitic agent-9 Related Antibodies

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Description

Antiparasitic agent-9 (compound 47) is an orally active and potent antiparasitic agent. Antiparasitic agent-9 shows antiparasitic activity against the human parasite[1].

IC50 & Target

Mite

 

In Vivo

Antiparasitic agent-9 (compound 47) (15 mg/kg, Orally, twice each day for 7 days) reduces adult worm burden in the jird L. sigmodontis infection model[1].
Antiparasitic agent-9 (2 mg/kg (IV), 10 and 30 mg/kg (PO); once) shows a brain to plasma ratio of 0.08, suggesting limited brain exposure[1].
Pharmacokinetic Parameters of Antiparasitic agent-9 in male Male CD-1 mouse[1].

PO (30 mg/kg) PO (10 mg/kg) IV (2 mg/kg)
Cmax (μM) 13.9 5.27 ± 0.83
Tmax (h) 0.50 4.0 ± 2.8
AUC0-inf (μM·h) 121 68.1±NC
CL (mL/min/kg) 3.6 ± 0.22
Vd ss (mL/kg) 0.74 ± 0.08
F (%) 57
brain/plasma [b]/[p] 0.08
efflux ratio (ER) 12

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (infected withL. sigmodontis, 6-8 weeks)[1]
Dosage: 15 mg/kg
Administration: Orally, twice each day for 7 days
Result: Showed a significant worm burden reduction of 59% at 15 mg/kg.
Animal Model: Male CD-1 mouse (n = 4)[1]
Dosage: 2 mg/kg (IV), 10 and 30 mg/kg (PO)
Administration: IV, PO, once (Pharmacokinetic Analysis)
Result: Showed a brain to plasma ratio of 0.08, suggesting limited brain exposure.
Molecular Weight

384.46

Formula

C18H20N6O2S
CAS No.
SMILES

CC(N(C1=CC=CN=C1NC2=NC(C3=NC=C(OC(C)C)C=C3)=NS2)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiparasitic agent-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiparasitic agent-92516237-50-4Antiparasitic agent9Antiparasitic agent 9ParasiteCaco-2 cellsL. sigmodontisAntiparasiticwormparasiteInhibitorinhibitorinhibit

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