2. Anti-infection
  3. Fungal
  4. Antiproliferative agent-18

Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity.

For research use only. We do not sell to patients.

Antiproliferative agent-18 Chemical Structure

Antiproliferative agent-18 Chemical Structure

CAS No. : 2882206-14-4

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Antiproliferative agent-18 Related Antibodies

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Description

Antiproliferative agent-18 (Compound 5k) is an anti-proliferative agent. Antiproliferative agent-18 also displays moderate anti-bacterial and anti-fungi activity[1].

IC50 & Target

Bacteria, Fungi[1]
In Vitro

Antiproliferative agent-18 (Compound 5k) (200 µg/ /8 mm disc; 24 h for bacteria, 48 h for fungi) displays moderate antibacterial activity (growth inhibition zones 14–17 mm) and is moderately active against the yeast-like pathogenic fungus Candida albicans (growth inhibition zone 17 mm)[1].
Antiproliferative agent-18 (0.1-100 μM; 48 h) shows anti-proliferative activity against human prostate cancer (PC-3), colorectal carcinoma (HCT-116), hepatocellular carcinoma (HepG-2), epithelioid cervical carcinoma (HeLa) and mammary gland breast cancer (MCF-7) cell lines[1].
Antiproliferative agent-18 occupies the positions of NAD cofactor and the histone deacetylase inhibitor EX527 at the active site of SIRT1 enzyme[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-18 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: PC-3, HCT-116, HepG-2, HeLa and MCF-7 cells
Concentration: 0.1-100 μM
Incubation Time: 48 h
Result: Showed anti-proliferative activity with IC50s of 9.71 ± 0.8, 6.47 ± 0.5, 11.27 ± 0.9, 7.09 ± 0.5 and 3.51 ± 0.2 μM against PC-3, HCT-116, HepG-2, HeLa and MCF-7 cells, respectively.
Molecular Weight

434.57

Formula

C26H27FN2OS
CAS No.
SMILES

COC1=CC=C(C2=CS/C(N2C3=CC=C(F)C=C3)=N\C45CC6CC(C5)CC(C6)C4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiproliferative agent-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-182882206-14-4Antiproliferative agent18Antiproliferative agent 18FungalPC-3HCT-116HepG-2HeLaMCF-7Candida albicansInhibitorinhibitorinhibit

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