Antiproliferative agent-20 

Antiproliferative agent-20 is a potent and orally active anticancer agent. Antiproliferative agent-20 exhibits antiproliferative and anti-angiogenic activities^[1].

Antiproliferative agent-20 (compound 5) (3.125 -50.0 μM; 24-96 h) inhibits the proliferation of Bel-7402 cells in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-20 (10-40 μg/egg) inhibits the angiogenesis of the chick chorioallantoic membrane (CAM)^[1].
Antiproliferative agent-20 (3.2 g/kg; p.o.) shows no deaths or signs of toxicity in mice during two weeks^[1].
Antiproliferative agent-20 (24 h) does not be hydrolyzed in 37℃ artificial gastric juice and artificial intestinal liquid^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

418.40

C₂₃H₁₈N₂O₆

1344715-94-1

O=C(C(C=C1C2=O)=CC(O)=C1C(C3=C2C=CC=C3O)=O)OCC4=NC(C)=C(C)N=C4C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. WANG PL, et, al. Synthesis and Antitumor Evaluation of One Novel Tetramethylpyrazine-Rhein Derivative. Asian Journal of Chemistry (2013), 25(9), 4885-4888.