1. Autophagy NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
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  3. Antiproliferative agent-5

Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer.

For research use only. We do not sell to patients.

Antiproliferative agent-5 Chemical Structure

Antiproliferative agent-5 Chemical Structure

CAS No. : 2459892-41-0

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Description

Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer[1].

IC50 & Target

ROS, Autophagy[1]

Cellular Effect
Cell Line Type Value Description References
A549 GI50
> 10 μM
Compound: 4o
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
BGC-823 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
EJ GI50
> 10 μM
Compound: 4o
Antiproliferative activity against human EJ cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human EJ cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
HGC-27 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
MGC-803 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
MKN-45 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
SGC-7901 GI50
0.64 μM
Compound: 4o
Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell growth at measured after 72 hrs by SRB assay
[PMID: 32683165]
SW-620 IC50
0.058 μM
Compound: 24
Reversal of resistance to paclitaxel-induced cytotoxicity in human SW-620/AD300 cells assessed as reduction in paclitaxel IC50 at 1 uM preincubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4.23 +/- 0.50 uM)
Reversal of resistance to paclitaxel-induced cytotoxicity in human SW-620/AD300 cells assessed as reduction in paclitaxel IC50 at 1 uM preincubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4.23 +/- 0.50 uM)
[PMID: 34723530]
Molecular Weight

597.49

Formula

C28H21BrN8OS

CAS No.
SMILES

O=C(C1=CC=C(NC2=CC(C)=NC3=NC(SCC4=NC5=CC=CC=C5N4)=NN23)C=C1)/C=C/C6=NC(Br)=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antiproliferative agent-5
Cat. No.:
HY-146390
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