2. Apoptosis
  3. Apoptosis
  4. Antiproliferative agent-61

Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2.

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Antiproliferative agent-61 Chemical Structure

Antiproliferative agent-61 Chemical Structure

CAS No. : 1613078-24-2

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Description

Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2[1].

Molecular Weight

358.39

Formula

C22H18N2O3
CAS No.
SMILES

O=C(/C=C/C1=NC=CC2=C1NC3=C2C=CC=C3)C4=CC=C(C(OC)=C4)OC
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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Antiproliferative agent-61 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-611613078-24-2Antiproliferative agent61Antiproliferative agent 61ApoptosisInhibitorinhibitorinhibit

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