Antitrypanosomal agent 12 

Antitrypanosomal agent 12 is a C20-phenylthiourea with trypanocidal and cytotoxic activities. Antitrypanosomal agent 12 shows antitrypanosomal activity with 50% growth inhibition (GI₅₀) values of 0.22 μM. Antitrypanosomal agent 12 induces faster cell swelling in bloodstream-form trypanosomes than Salinomycin (HY-15597)^[1].

Antitrypanosomal agent 12 (compound 4d) (100 mM; 60 min) displays faster cell swelling activity than native Salinomycin in T. brucei bloodstream forms^[1].
Antitrypanosomal agent 12 shows selectivity on T. brucei over HL-60 cells with MIC values of 1 μM (T. brucei), and 10 μM (HL-60 cells), respectivley^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

909.20

C₄₉H₇₇N₂NaO₁₀S

CC[C@H]([C@@H]1[C@@H](C)C[C@@H](C)[C@@]2(CC[C@H](NC(NC3=CC=CC=C3)=S)[C@@]4(O[C@@]([C@@H]5O[C@@H](C)[C@@](O)(CC)CC5)(C)CC4)O2)O1)C([C@H]([C@@H](O)[C@H](C)[C@]6([H])O[C@@H]([C@H](C(O[Na])=O)CC)CC[C@@H]6C)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Antoszczak M, et al. Synthesis of urea and thiourea derivatives of C20-epi-aminosalinomycin and their activity against Trypanosoma brucei. Eur J Med Chem. 2023 Mar 15;250:115241.  [Content Brief]