2. Anti-infection
  3. Parasite
  4. Antitrypanosomal agent 9

Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research.

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Antitrypanosomal agent 9 Chemical Structure

Antitrypanosomal agent 9 Chemical Structure

CAS No. : 438474-67-0

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Based on 1 publication(s) in Google Scholar

Antitrypanosomal agent 9 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research[1].

IC50 & Target

Trypanosoma

 

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
1.15 μM
Compound: 1
Antitrypanosomal activity against Trypanosoma brucei brucei infected in HEK293 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
Antitrypanosomal activity against Trypanosoma brucei brucei infected in HEK293 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay
10.1039/C4MD00406J
L6 IC50
107 μM
Compound: 1
Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 96 hrs by beta-galactosidase reporter gene assay
Antitrypanosomal activity against trypomastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 96 hrs by beta-galactosidase reporter gene assay
10.1039/C4MD00406J
L6 IC50
186 μM
Compound: 1
Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
Cytotoxicity against rat L6 cells after 70 hrs by resazurin dye-based fluorometric analysis
10.1039/C4MD00406J
In Vitro

Antitrypanosomal agent 9 (compound 1) shows inhibitory activity against T. b. rhodesiense, T. cruzi, L. donovani, and P. falciparum, with IC50 values of 0.985 ± 0.076, 107 ± 34.5, 35.7 ± 6.22, and 22.3 ± 1.06 μM, respectively[1].
Antitrypanosomal agent 9 shows cytotoxicity in L6 cells, with an IC50 of 186 ± 94.2 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitrypanosomal agent 9 Related Antibodies
Molecular Weight

353.45

Formula

C22H27NO3
CAS No.
Appearance

Powder

Color

Light brown to brown

SMILES

N1(CCCC(C)C1)C(=O)C1C=CC(COC2C=CC(OCC)=CC=2)=CC=1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Antitrypanosomal agent 9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitrypanosomal agent 9438474-67-0Antitrypanosomal agent9Antitrypanosomal agent-9Parasiterat skeletal myoblastsL6 cellsT. b. rhodesienseT. cruziL. donovaniP. falciparumantitrypanosomalhuman African trypanosomiasisHATInhibitorinhibitorinhibit

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