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  4. Antitumor agent-162

Antitumor agent-162 (compound 52a) is a potent and orally active antitumor agent. Antitumor agent-162 shows cytotoxicity.

For research use only. We do not sell to patients.

Antitumor agent-162 Chemical Structure

Antitumor agent-162 Chemical Structure

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Antitumor agent-162 Related Antibodies

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Description

Antitumor agent-162 (compound 52a) is a potent and orally active antitumor agent. Antitumor agent-162 shows cytotoxicity[1].

In Vitro

Antitumor agent-162 (compound 52a) (0-5000 nM) shows cytotoxicity with IC50s of 63, 84 nM for Mut6, UTSW63 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-162 Related Antibodies
In Vivo

Pharmacokinetic Parameters[1].

route T1/2 (h) Cmax (ng/mL) Tmax (h) AUClast (ng*min/mL) CL kp (AUCbrain/AUCplasma)
plasma i.p. (10 mg/kg) 234 1303 30 289860 0.13 -
i.v. (5 mg/kg) 189 12000 5 885630 0.14 -
p.o. (20 mg/kg) 208 3404 30 1387613 0.14 -
brain i.p. (10 mg/kg) 182 2526 90 720503 - 2.49
i.v. (5 mg/kg) 294 3257 5 767638 - 0.87
p.o. (20 mg/kg) 254 2381 90 1774789 - 1.28

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

480.34

Formula

C26H19Cl2NO4
SMILES

ClC1=CC(Cl)=CC(C(COC2=CC=C(C=C2)N3C(C4C(C5C6CC6C57C=CC47)C3=O)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-162 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-162Antitumor agent162Antitumor agent 162Othersorally activeantitumorcytotoxicityMut6UTSW63 cellInhibitorinhibitorinhibit

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HY-162560
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