2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. Antitumor agent-177

Antitumor agent-177 (compound 57), a non-steroidal NSC12 derivative, shows potent FGF2 binding affinity with a Kd of 24 μM by SPR. Antitumor agent-177 significantly inhibits the formation of HSPG/FGF2/FGFR1 ternary complexes. Antitumor agent-177 inhibits FGFR activation and exerts a potent anti-tumor activity on multiple myeloma (MM) cell lines in vitro and in vivo.

For research use only. We do not sell to patients.

Antitumor agent-177 Chemical Structure

Antitumor agent-177 Chemical Structure

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Antitumor agent-177 Related Antibodies

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Description

Antitumor agent-177 (compound 57), a non-steroidal NSC12 derivative, shows potent FGF2 binding affinity with a Kd of 24 μM by SPR. Antitumor agent-177 significantly inhibits the formation of HSPG/FGF2/FGFR1 ternary complexes. Antitumor agent-177 inhibits FGFR activation and exerts a potent anti-tumor activity on multiple myeloma (MM) cell lines in vitro and in vivo[1].

IC50 & Target[1]

FGFR

 

Molecular Weight

554.45

Formula

C28H21F7O4
SMILES

OC(C1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C(COC4=CC=C(F)C=C4)=C1)CC(O)(C(F)(F)F)C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-177 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-177Antitumor agent177Antitumor agent 177FGFRFibroblast growth factor receptornon-steroidalNSC12FGF2multiple myelomaHSPG/FGF2/FGFR1Inhibitorinhibitorinhibit

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