2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-180

Antitumor agent-180 (Compound 13a) is an inhibitor for BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B). Antitumor agent-180 inhibits the proliferation of ccRCC cell Caki-1 with IC50 of 2.047 µM. Antitumor agent-180 induces necrosis and apoptosis in Caki-1.

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Antitumor agent-180 Chemical Structure

Antitumor agent-180 Chemical Structure

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Antitumor agent-180 Related Antibodies

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Description

Antitumor agent-180 (Compound 13a) is an inhibitor for BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B). Antitumor agent-180 inhibits the proliferation of ccRCC cell Caki-1 with IC50 of 2.047 µM. Antitumor agent-180 induces necrosis and apoptosis in Caki-1[1].

Molecular Weight

591.75

Formula

C34H41N9O
SMILES

CN(CC1)CCN1C2=CC=C(NC3=C(C)C=NC(NC4=CC=C(C(NC5=CC=C(N6CCN(C)CC6)C=C5)=O)C=C4)=N3)C=C2
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Antitumor agent-180 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-180Antitumor agent180Antitumor agent 180Apoptosisclear cell renal cell carcinomaccRCCCaki-1Inhibitorinhibitorinhibit

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