Antitumor agent-201 

Antitumor agent-201 (Compound 10) is a chloride transport activator that targets the Golgi apparatus. Its EC₅₀ for promoting the transmembrane transport of chloride ions is 1.53 mol%, and its IC₅₀ against HepG2 cells is 7.13 μM. Antitumor agent-201 exerts its anti-cancer activity by selectively acting on the Golgi apparatus, disrupting the chloride ion homeostasis within it, reducing the expression of key proteins such as GM130 and GRASP55, altering the structure and function of the Golgi apparatus, triggering Autophagy of the Golgi apparatus, and further inducing Apoptosis of cancer cells and arresting cancer cells in the G2/M phase. Antitumor agent-201 can be used in the research field of cancer diseases^[1].

592.51

C₂₄H₂₂F₆N₄O₅S

O=S(C1=CC=C(NC(CCCCCNC2=C(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C(C2=O)=O)=O)C=C1)(N)=O

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• [1]. Yang H, et al. Design, synthesis and biological evaluation of Golgi-targeting anion transporters as inducers of Golgiphagy and apoptosis in cancer cells. Eur J Med Chem. 2025 Jun 5;290:117519.