2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. Antitumor agent-28

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity.

For research use only. We do not sell to patients.

Antitumor agent-28 Chemical Structure

Antitumor agent-28 Chemical Structure

CAS No. : 2097499-67-5

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Antitumor agent-28 Related Antibodies

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Description

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

IC50 & Target[1]

ATM

 

ATR

 

In Vitro

Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC50=7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC50=18 μM; HT29 cells), PI3Ka (IC50=0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-28 Related Antibodies
Molecular Weight

512.62

Formula

C25H32N6O4S
CAS No.
SMILES

O=C(N1C(C)C)N(C)C2=C1C3=CC(C4=CC=C(N5CC(N(C)C)C5)N=C4)=CC=C3N=C2.CS(=O)(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-28 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-282097499-67-5Antitumor agent28Antitumor agent 28ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedHT29ataxiatelangiectasiaRad3PI3KaBT474MDA-MB-468Inhibitorinhibitorinhibit

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