1. Cell Cycle/DNA Damage Apoptosis
  2. DNA/RNA Synthesis Apoptosis
  3. Antitumor agent-43

Antitumor agent-43 (Compound 4B) is a potent antitumor agent, with an IC50of 0.5 µM for (T-24 cell). Antitumor agent-43 (Compound 4B) induces cell cycle arrest at G2/M phase.

For research use only. We do not sell to patients.

Antitumor agent-43 Chemical Structure

Antitumor agent-43 Chemical Structure

CAS No. : 2766035-37-2

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Description

Antitumor agent-43 (Compound 4B) is a potent antitumor agent, with an IC50of 0.5 µM for (T-24 cell). Antitumor agent-43 (Compound 4B) induces cell cycle arrest at G2/M phase[1].

In Vitro

Antitumor agent-43 towards T-24, MGC80-3, SK-OV-3, HepG2 cells with IC50of 0.5, 1.1, 8.9 and 1.3µM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor agent-43 effectively inhibits tumor growth (49.5%) in a mouse xenograft model bearing T-24. [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

276.25

Formula

C16H8N2O3

CAS No.
SMILES

O=C1C2=NC=CC3=C([N+]([O-])=O)C=CC(C4=C1C=CC=C4)=C23

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Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antitumor agent-43
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HY-144340
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