2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-62

Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase.

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Antitumor agent-62 Chemical Structure

Antitumor agent-62 Chemical Structure

CAS No. : 2460735-29-7

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Antitumor agent-62 Related Antibodies

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Description

Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase[1].

In Vitro

Antitumor agent-62 (Compound 47) shows antiproliferative activity with IC50 values of 1.23 ± 0.10, 1.91 ± 0.14, 2.81 ± 0.13, 4.18 ± 0.15 and 9.16 ± 0.38 μM against MDA-MB-231, MCF-7, HepG2, A549 and LO2 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-62 Related Antibodies
Molecular Weight

489.46

Formula

C21H19N3O9S
CAS No.
SMILES

O=C1OC2=C(C=C1N)C=C(OC)C(OCCCOC3=NO[N+]([O-])=C3S(=O)(C4=CC=CC=C4)=O)=C2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Antitumor agent-62 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-622460735-29-7Antitumor agent62Antitumor agent 62ApoptosisMDA-MB-231MCF-7HepG2A459anticancerlow toxicityInhibitorinhibitorinhibit

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