Antitumor agent-62

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Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase.

For research use only. We do not sell to patients.

Antitumor agent-62 Chemical Structure

CAS No. : 2460735-29-7

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	4.18 μM Compound: 47	Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay Anticancer activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay	[PMID: 32438251]
HepG2	IC₅₀	2.81 μM Compound: 47	Anticancer activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay	[PMID: 32438251]
L02	IC₅₀	9.16 μM Compound: 47	Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32438251]
MCF-10A	IC₅₀	6.45 μM Compound: 5	Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34315044]
MCF7	IC₅₀	1.91 μM Compound: 47	Anticancer activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay	[PMID: 32438251]
MCF7	IC₅₀	2.02 μM Compound: 5	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 34315044]
MDA-MB-231	IC₅₀	1.39 μM Compound: 5	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 34315044]

In Vitro

Antitumor agent-62 (Compound 47) shows antiproliferative activity with IC₅₀ values of 1.23 ± 0.10, 1.91 ± 0.14, 2.81 ± 0.13, 4.18 ± 0.15 and 9.16 ± 0.38 μM against MDA-MB-231, MCF-7, HepG2, A549 and LO2 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

489.46

Formula

C₂₁H₁₉N₃O₉S

CAS No.

2460735-29-7

SMILES

O=C1OC2=C(C=C1N)C=C(OC)C(OCCCOC3=NO[N+]([O-])=C3S(=O)(C4=CC=CC=C4)=O)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shi Z, et al. Novel NO-releasing scopoletin derivatives induce cell death via mitochondrial apoptosis pathway and cell cycle arrest. Eur J Med Chem. 2020 Aug 15;200:112386. [Content Brief]