Antitumor agent-71

Cat. No.: HY-146250: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Antitumor Agent-71 is an antiproliferative activity antitumor agent and against tumor cell lines with IC₅₀ values ranging from 3.98-15.70 μM. Antitumor Agent-71 is an antitumor agent that can inhibit tubulin polymerization.

For research use only. We do not sell to patients.

Antitumor agent-71 Chemical Structure

CAS No. : 2011756-99-1

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

3.98/15.70/10.48/5.38 μM

In Vitro

Antitumor agent-71 (0.002-20 μM; 48 hours) inhibits the cell line HepG2, MCF-7, MIA PaCa-2, and Bel-7402 growth in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	HepG2, MCF-7, MIA PaCa-2, and Bel-7402^[1].
Concentration:	0.002-20 μM
Incubation Time:	48h
Result:	Showed antitumor activity against HepG2, MIA PaCa-2, MCF-7, and Bel-7402 cell lines with the IC₅₀ values of 3.98/15.70/10.48/5.38 μM.

In Vivo

Antitumor agent-71 (10-20 mg/kg; intravenous injection; twice a day; 20 days) shows inhibitory effects and inhibits HepG2 cell line in nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HepG2 model BALB/c nude mice^[1]
Dosage:	10mg/kg, 20mg/kg
Administration:	Intravenous injection; twice a day; 20 days
Result:	Inhibited tumor growth in a dose-dependent manner.

Molecular Weight

509.62

Formula

C₂₆H₃₁N₅O₄S

CAS No.

2011756-99-1

SMILES

O=S(C1=CC2=C(C=C1)N(C)C3=C2C=C(CN4CCN(C)CC4)C=C3)(NC5=CC=C(OC)N=C5OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lianqi Sun, et al. Design, synthesis, and evaluations of the antiproliferative activity and aqueous solubility of novel carbazole sulfonamide derivatives as antitumor agents. Bioorg Chem. 2020 Jun;99:103766. [Content Brief]