2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-79

Antitumor agent-79 shows good antiproliferative activities against hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7-7.9 μM. Antitumor agent-79 induces cancer cells apoptosis and shows in vivo antitumor effects. Antitumor agent-79 can be used for the research of cancer.

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Antitumor agent-79 Chemical Structure

Antitumor agent-79 Chemical Structure

CAS No. : 2750233-50-0

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Antitumor agent-79 Related Antibodies

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Description

Antitumor agent-79 shows good antiproliferative activities against hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7-7.9 μM. Antitumor agent-79 induces cancer cells apoptosis and shows in vivo antitumor effects. Antitumor agent-79 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.7 μM (Huh7), 1.4 μM (HepG2), 1.5 μM (SNU475), 7.9 μM (Hep3B), 2.4 μM (FOCUS), 5.2 μM (Hep40), 6.5 μM (PLC-PRF-5), 3.7 μM (Mahlavu), 0.9 μM (MCF7), 0.9 μM (MDA-MB231), 1.0 μM (MDA-MB468), 1.8 μM (SKBR3), 5.5 μM (ZR75), 7.6 μM (MCF10A)[1]
In Vitro

Antitumor agent-79 (0.15-40 μM; 72 h) shows in vitro growth inhibitory activities against hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7-7.9 μM[1].
Antitumor agent-79 (5 μM; 48 h) induces cell apoptosis by increasing the PARP cleavage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-79 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Huh7, HepG2, SNU475, Hep3B, FOCUS, Hep40, PLC-PRF-5, Mahlavu, MCF7, MDA-MB231. MDA-MB468, SKBR3, ZR75 and MCF10A cell lines
Concentration: 0.15-40 μM
Incubation Time: 72 hours
Result: Time and dose-dependent showed cytotoxicity to hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7, 1.4, 1.5, 7.9, 2.4, 5.2, 6.5, 3.7, 0.9, 0.9, 1.0, 1.8, 5.5 and 7.6 μM for Huh7, HepG2, SNU475, Hep3B, FOCUS, Hep40, PLC-PRF-5, Mahlavu, MCF7, MDA-MB231, MDA-MB468, SKBR3, ZR75 and MCF10A cells, respectively.

Western Blot Analysis[1]

Cell Line: Mahlavu, Huh7, MCF-7 and MDA-MB-231 cancer cells
Concentration: 5 μM
Incubation Time: 48 hours
Result: Increased the PARP cleavage in both breast cancer cells (MCF7 and MDA-MB-231) and hepatocellular carcinoma cells (Mahlavu).

Apoptosis Analysis[1]

Cell Line: Mahlavu, Huh7, MCF-7 and MDA-MB-231 cancer cells
Concentration: 5 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis of cancer cells.
In Vivo

Antitumor agent-79 (40 mg/kg; p.o. twice a week for 4 weeks) shows antitumor effects in mice xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6−8 weeks old male athymic nude mice with hepatocellular carcinoma (Mahlavu cells) and breast (MDA MB-231 cells) xenografts[1]
Dosage: 40 mg/kg
Administration: Oral gavage; 40 mg/kg; twice a week for 4 weeks
Result: Significantly reduced the tumor volume following 4 weeks treatment with 40% reductions of tumor volumes in the Mahlavu xenografts. Resulted in about a 50% decreased in tumor volumes as compared to the control group in MDA-MB-231 xenografts. Showed well tolerated in vivo and neither significant bodyweight loss nor toxic effects or mortality were observed.
Molecular Weight

374.86

Formula

C23H19ClN2O
CAS No.
SMILES

CC1=CC=CC=C1COC2=CC=C(C3=CC=NN3C4=CC=C(Cl)C=C4)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-79 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-792750233-50-0Antitumor agent79Antitumor agent 79ApoptosisisoxazolepyrazolederivativeantiproliferativeantitumorapoptosiscancerInhibitorinhibitorinhibit

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