2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-80

Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells.

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Antitumor agent-80 Chemical Structure

Antitumor agent-80 Chemical Structure

CAS No. : 2758520-84-0

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Antitumor agent-80 Related Antibodies

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Description

Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells[1].

In Vitro

Antitumor agent-80 (compound 11) (5 μM, 48 h) induces apoptosis and increase in PARP cleavage in tumor cells[1].
Antitumor agent-80 (0-10 μM, 96 h) shows cell growth inhibitory activity against breast and hepatocellular carcinoma cell lines[1].
Growth Inhibitory Activity of Antitumor agent-80 against Hepatocellular Carcinoma and Breast Cancer Cell Line Panel[1].

hepatocellular carcinoma IC50 (μM) breast IC50 (μM)
Huh7 1.3 MCF7 3.8
HepG2 2.1 MDA-MB231 2.0
SNU475 1.7 MDA-MB468 2.8
Hep3B 3.0 SKBR3 3.5
FOCUS 2.1 ZR75 7.6
Hep40 8.6 MCF10A 12.1
PLC-PRF-5 9.5
Mahlavu 3.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-80 Related Antibodies

Western Blot Analysis[1]

Cell Line: Huh7, Mahlavu, MDA-MB-231, and MCF-7 cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Caused the increase in PARP cleavage in both breast cancer cells (MCF7 and MDA-MB-231) and hepatocellular carcinoma cells (Mahlavu).

Cell Proliferation Assay[1]

Cell Line: Huh7, Mahlavu, MDA-MB-231, and MCF-7 cells
Concentration: 10 μM, 5 μM, 2.5 μM
Incubation Time: 96 h
Result: Caused inhibition in the growth of both breast and hepatocellular carcinoma cell lines.
In Vivo

Antitumor agent-80 (compound 11) (40 mg/kg, Orally, twice a week, for 4 weeks) displays antitumor activity in vivo in the Mahlavu hepatocellular carcinoma and the MDA-MB-231 breast cancer xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (6-8 weeks old, with Mahlavu cells or MDA-MB-231 cells)[1]
Dosage: 40 mg/kg
Administration: Orally, twice a week, for 4 weeks
Result: In the Mahlavu xenografts, had a significant reduction (85%) in tumor volume. For MDA-MB-231 xenografts, resulted in about a 50% decrease in tumor volumes as compared to the control group.
Molecular Weight

389.87

Formula

C24H20ClNO2
CAS No.
SMILES

CC1=CC=CC=C1COC2=CC=C(C3=NOC(C)=C3C4=CC=C(Cl)C=C4)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Antitumor agent-80 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-802758520-84-0Antitumor agent80Antitumor agent 80Apoptosisdiaryl isoxazoleMahlavuhepatocellular carcinomabreast cancerMCF7Huh7antitumorMDA-MB231Inhibitorinhibitorinhibit

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